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 CUTTING EDGE TECHNOLOGY TO BIOPRINT MINI-KIDNEYS! 


Using 3D bioprinting technology, the researchers produced miniature human kidneys in the lab. The study includes biotech company Organovo, Murdoch Children's Research Institute (MCRI).

The research team also validated the use of 3D bioprinted human mini-kidneys to screen for drug toxicity from a class of drugs known to cause kidney damage in humans. The study demonstrated how 3-D bioprinting of stem cells would produce sheets of kidney tissue large enough for transplants.

Artificial living tissue was produced using extrusion-based 3D bioprinting technology and bioink consisting of stem cells.

Melissa Little, who started growing kidney organoids in 2015, stated that the 3D bioprinting method allows a faster and more reliable process. The study found that with 3D bioprinting, it was able to create about 200 mini-kidneys in 10 minutes without sacrificing quality.

The mini-kidneys produced resemble a normal-sized kidney. Using mini-organs, drugs will be screened to find new treatments for kidney disease. It will also be tested whether a new drug is likely to damage the kidney. The toxicity of aminoglycosides, a class of kidney-damaging antibiotics, was also tested in this study. Professor Little stated that they found that the death of certain cell types increased in kidneys treated with aminoglycosides.


Credit : https://www.technologynetworks.com/cell-science/news/3d-bioprinting-improves-kidney-organoid-generation-343142


REFERENCES

Cutting edge technology to bioprint mini-kidneys

Cellular extrusion bioprinting improves kidney organoid reproducibility and conformation

Kynan T. Lawlor

Jessica M. Vanslambrouck

J. William Higgins

Alison Chambon

Kristina Bishard

Pei Xuan Er

Sean B. Wilson

Sara E. Howden

Ker Sin Tan

Fanyi Li

Lorna J. Hale

 Derek Arndt

Benjamin Shepherd

 Stephen Pentoney

Sharon C. Presnell

Alice E. Chen









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